What is DOC?

DOC (2,5‐dimethoxy‐4‐chloramphetamine) is a synthetic psychedelic. Depending on the dose, a trip can last up to 12-24 hours. It is available as a fine, white crystal-like powder, as a pill or as a papertrip (paper square of about 1×1 cm). There may be a logo on the tablet, but it doesn’t have to.

DOC sometimes occurs as contamination in other drugs. For example, in papertrips sold as LSD, or pills sold as MDMA or 2C-B. Therefore, always have your drugs tested.


DOC is a stimulant psychedelic. The stimulating effects are strong. You get more energy, you can feel restless and suffer from muscle tension.

Positive effects (negatieve) Side effects


In hallucinations you perceive things that are not there. It really is an observation that seems to be real. For example, you may hear sounds (auditory hallucinations) or see something or someone (visual hallucination). This is in contrast to a change in sensory perception where normal perception is distorted. Think of a person’s voice that sounds higher or lower or a face that seems to have a big nose.

Hallucinations can be both desirable effects (with psychedelics) and unwanted side effects (with high doses of MDMA, or with being awake for too long).

Paranoia and delusions

Anxiety, paranoia and delusions (e.g. the idea that people are talking about you).

Euphoria, feelings of love

This substance can make you feel euphoric, like you are in love. You feel comfortable in your own skin and can experience things as pleasant more quickly.

Increase in blood pressure and heart rate

Due to increased cardiac stimulation, heart rate and blood pressure rise.

Laughing fits

Spontaneous and uncontrollable laughter, sometimes without anything humorous happening.

Increased body temperature

Stimulants cause increased activity in muscles, and increase the “base temperature” of the body. This causes the body temperature to increase.

Altered sensory perception

How you perceive your environment changes, this can affect all of your senses. Sometimes, this could make it seem as if your surroundings differ from reality. More information about tripping and hallucinations can be found here.


Some drugs keep you from falling asleep. Stimulants often have this effect, but even after using psychedelics or downers, sleep is disrupted and it is possible that you can’t sleep.

Changes in perception of time

The passage of time could feel altered during ketamine use. Some parts of the evening fly by, while some parts feel a lot slower. When you are feeling comfortable, it can be nice that the feeling does not seem to stop. But if you feel uncomfortable, this can be a bothersome experience. So this effect can work both ways.

Decreased appetite

Stimulation of the fight-or-flight response in the body can suppress appetite.

Changes in thought patterns

You more quickly form logical and illogical associations, but your thoughts may also become more chaotic and confused. For the user, this could be either a positive or negative experience.


An uneasy and tense feeling in the abdomen, which may cause discomfort. Nausea often precedes vomiting.

Energetic feeling

You have feelings of being energized. Sitting still is sometimes more difficult and this energetic feeling is often expressed through the urge to dance or move.

Dilated pupils

Due to an increased noradrenaline level in the body after taking certain drugs, the pupils become larger. The pupil size is influenced by many different processes. Increase in noradrenaline plays a role in some of those processes.

Teeth grinding

Grinding your teeth

Changes in thought patterns

You more quickly form logical and illogical associations, but your thoughts may also become more chaotic and confused. For the user, this could be either a positive or negative experience.

Dry mouth

Stimulation of sympathetic pathways decrease saliva production, this causes the mouth to feel dry.

Dose and route of administration

DOC is usually taken orally. Sometimes in pill form, sometimes on a papertrip. DOC is a very potent substance. You only need a little to have strong psychedelic effects.

Doseringen bij slikken
Light dose 1 – 2 mg
Medium dose 2 – 4 mg
High dose 4 – 6 mg


It may take 2 to 3 hours for DOC to start working. The effects of DOC can last for 12 to 24 hours.


Little is known about the long-term risks of DOC.

It can take up to 2 to 3 hours for DOC to start working. The effects then last for 12 to 24 hours. Since DOC is more physically stimulating than other psychedelics, and the psychedelic effects can also be more intense, this can quickly become too much. Especially with a lack of sleep, it is more difficult to control than short acting psychedelics.

Short term risks

Triggering a drug-induced psychosis

Frequent and high-dosage ketamine use can increase susceptibility to developing psychosis. During a psychosis, you may suffer from delusions, hallucinations, losing your grip on reality, and you could become very anxious. It becomes difficult to differentiate between reality and your thoughts. Your behaviour and thought patterns are often erratic and chaotic.

It is still unclear whether this can only be triggered in people who are already predisposed to psychosis, or whether regular drug use and an unhealthy lifestyle (e.g. little sleep) by itself can induce psychosis.

Using ketamine consecutively for days without sleeping, resting and eating exhausts your body, and therefore increases the risks of psychosis. Does someone in your environment react erratic and anxious? You can help that person by removing distractions (music, TV off for a while) and finding another environment where that person can get some rest. Speak calmly, be understanding and, if necessary, go outside together. Do not deny or confirm any delusions and if it does not get better, call a general practice centre. Medical staff are there to help you and can, if necessary, arrange a consult, write a prescription or provide care in another way.

Read more about psychosis in this article.

Experiencing a bad trip

You may be overwhelmed by the intensity of your ketamine experience. Such an experience can certainly be frightening for inexperienced users, and is called a ‘bad trip’. A bad trip, for example, manifests itself in confusion as a result of a dose that was too high. However, it can also arise because someone no longer has his/her thoughts under control.

In such a situation, it is important to put the person’s mind at ease. Explain to them that the situation they are in is a result of the drug and that things will be well again in a short time.

Give the person in question as much rest as possible, preferably in a familiar environment. Accepting the situation is often the first step a person needs to take to sit out the trip in calmer waters. Using hallucinogens when you are not feeling well or in an unfamiliar/busy environment increases the chance of unpleasant experiences during the trip and is therefore not recommended.

Read more.

Vasoconstriction (blood vessel contraction)

Stimulation of the sympathetic (fight-or-flight response) nervous system causes blood vessels supplying some organs to constrict, in order to increase relative blood flow to the muscles.


Overheating (hyperthermia) can occur when your body temperature rises too high. Using drugs in a hot, humid, crowded environment (such as a club or indoor party, or in the sun at an outdoor festival) will raise your body temperature even further. Combined with intense, long, uninterrupted dancing, overheating can occur.

Early symptoms of overheating;

  • Headache
  • Confusion
  • Stiff muscles
  • Dizziness

These are all symptoms that can also fall under the “normal” side effects of a drug. If the body temperature does not drop, the following symptoms may also occur:

  • Shivering
  • Elevated heart rate
  • Pale appearance
  • Impaired consciousness
  • Nausea
  • Vomiting

If the body temperature rises to 40-41 degrees Celsius, the situation is life-threatening:

  • Breakdown of muscle tissue
  • Blood clotting throughout the body
  • Impaired functioning of kidneys and liver
  • Epileptic seizure


Depending on circumstances, overheating may also occur with “normal” doses of a drug.

Overheating is very dangerous and difficult to treat. Attempting to cool down, resting, and drinking enough water (no more than one glass per hour) is necessary to prevent overheating. Sweating is also an important way to cool down: by evaporating the sweat on your skin, it cools down slightly. But if the ambient humidity is very high (when condensate drops fall from the ceiling), sweat can’t evaporate well enough and therefore your body can’t cool down properly.

Long term risks

Psychological dependency

When someone has a psychological dependency, they are convinced that they cannot function without using the substance.

However, there is no physical change in body chemistry that would produce bodily side effects from quitting the substance.

Hallucinogen Persisting Perception Disorder (HPPD)

HPPD is a condition in which a person has flashbacks to previously experienced hallucinations or distortions from a psychedelic trip. Read more about visual snow, HPPD, depersonalization and derealization.


Combining different types of drugs can be risky and unpredictable. When you combine drugs you can have a higher risk of health problems. In the following paragraphs you can read about the effects and the risks of a number of combinations that occur frequently and also a about few that are extra hazardous. Also check our theme combining drugs.

Psychedelics and alcohol

Because of the psychedelic you have energy and you are less tired. As a result, you may feel the sedating effects of the alcohol less and you may have a tendency to drink more alcohol. Be careful, because this can cause an extra large hangover. So do not drink alcohol when you are tripping or agree with yourself or your friends in advance how many glasses of alcohol you want to drink. This prevents headaches the next day and is better for your health!

It can also make the trip more vague. You have less control over the trip because of the alcohol. This gives a greater chance of a difficult experience. You are disinhibited by the alcohol. You may end up doing things that are stupid or dangerous. Especially if you can no longer think logically because you are tripping, this can lead to dangerous or unpleasant situations.

Benzodiazepines and psychedelics

A benzodiazepine may sound like a good solution if someone is having a difficult experience on a psychedelic. Read more about that here. In the best situation, however, you solve it in a different way. See also this article.

  • Persistent bad trip? Try to work it out yourself first, for example by talking to people in your environment, or by changing your environment.
  • Doesn’t all this work? And do you remain afraid or anxious? Then it is possible to take a benzodiazepine, because this inhibits the anxiety. For example, oxazepam (Seresta), and for long-term anxiety suppression diazepam (Valium).
  • Please note: your trip will become less, you will become less anxious, but in principle the drug will continue to work. Only you have a less anxious / intense experience of your trip.
  • Have you had a bad trip? Then find out what caused this. Was it your environment, your friends or are there things in your life that are not going well at the moment, which made your trip negative. You can learn from a bad trip and you can counteract this learning effect by using benzodiazepines. So don’t get into the habit of taking a benzodiazepine too easily to control your trip/turn yourself off.

Cannabis and psychedelics

If you smoke weed during a trip, it can make for a more intense trip. Keep that in mind. There are users who have later experienced that they relived certain trip effects while smoking weed, as a kind of vivid memory of a previous experience. This can be very scary and confusing. If you experience this, we advise you to stop smoking weed.
It can also suddenly change the direction or vibe of a trip. This new direction isn’t always positive. So before you smoke weed, think about whether it will improve the experience.

Laughing gas and psychedelics

If you are tripping and you take nitrous oxide, it can cause very intense effects. That can be fun, but it can also be so intense that it scares you. If you decide to combine, make sure you take the time and space for it. Find a quiet spot and sit or lie down.

Unity tips

  • DOC is a long acting psychedelic. Plan a day ahead and preferably take another few days to proces the experience and the recover.
  • Have your DOC tested to make sure it is DOC.

Unity tips for using psychedelics

  • When taking a psychedelic for the first time, try to have your experience in nature or at home
  • Do you want to trip at a party or festival? Adjust your dose to be smaller than what you are used to.
  • Prevent nausea by eating something easily digestible at least 2 hours before taking your drugs
  • Make sure to always have a sober person (a trip sitter) around when tripping.
  • Pay close attention to the effects you experience: if you feel that they are too strong or unpleasant, ingesting vitamin C, dextrose or sweet drinks may help to alleviate this.
  • Do not fight any unpleasant feelings during the trip, but let yourself float on the flow of the trip
  • Do not combine psychedelics with other drugs (including alcohol) and medications. Cannabis in particular can greatly intensify and prolong the effect of psychedelics.
  • Make sure you are free from responsibilities the day after using, take some time to process the experience
  • Do not use psychedelics if you suffer from epilepsy or have a cardiovascular disease.

Unity tips for using drugs

  • When using a drug for the first time, take only a small dose to see how your body reacts to the substance
  • Only use drugs when you are feeling well
  • Use drugs recreationally, not to combat psychological issues like fatigue
  • Avoid using drugs if you have (had) psychological afflictions or if you have a family history of psychological diseases (such as depression) in your family
  • Test your drugs before use at a drugs-testing service
  • Make sure to prepare a good set and setting for drug use
  • Only use drugs sparingly. Keep track of your use over time.
  • Decide in advance how much you are planning to use over the evening, and stick to that. 
  • Do not combine drugs with other substances or medicines
  • Do not participate in traffic after drug use
  • Prevent infectious diseases; Use your own snorter/sniffer and do not share paraphernalia with others
  • After insufflating, rinse your nose well with lukewarm saline water (for example, by using a nasal spray or nasal douche)
  • Are you, or one of your friends not feeling well? Keep an eye out for one another, take care of each other and visit the first aid (if one is available)
  • Call 112 in a life-threatening situation
  • Eat healthy before and after drug use. In particular, foods with lots of antioxidants and vitamins (blueberries, raspberries, blackberries, grapes, raisins, oranges, kiwi, broccoli). This is perhaps the most important tip! It can be difficult to eat during and after drug use, but make sure to try to eat something anyway. Eating well is a great way to reduce the hangover! If you can’t hold in solid foods, try juices, breakfast drinks, and smoothies.



Warning DOC in 2C-B

In April 2021, there was a warning about 2C-B pills that contain an extremely high dose of DOC. Always get your drugs tested! For more information about the warning, visit