Ecstasy/MDMA and antidepressive medication
If you’re depressed, it’s definitely not a good idea to take MDMA. If you’re on modern antidepressants, known as SSRIs, you will probably feel little to nothing from the MDMA. The effect of MDMA on the messenger substance serotonin is blocked in your brain. However, you can experience side effects of the MDMA that works on other messenger substances, such as noradrenaline and dopamine. These are mainly the effects that people do not want to have.
If you take an old type of antidepressant, called MAO inhibitors, it is very dangerous to use various drugs, including MDMA. Your blood pressure can rise to dangerous levels and you have a higher risk of serotonin syndrome.
MDMA also disrupts the balance in your brain. You may feel good for a while, but then you feel worse. This just makes it harder to feel better overall.