Some people say that GHB would prolong the action of MDMA. The combination can make you push your limits even more than the individual drugs. GHB and MDMA alone often cause someone to go further than they would do sober. The combination can enhance this effect. So keep that in mind. Don’t do things that you later regret.

Some people think that the combination of MDMA and/or amphetamine (speed) with GHB can prevent you from passing out. It is true that your mind may feel clearer than if you were taking GHB alone. But you can still pass out. There is some evidence that if you lose consciousness from a GHB overdose, your coma may be deeper and longer if you have also taken speed or MDMA. Therefore, never use uppers to avoid passing out.