I am planning to use a new substance. What do I need to keep in mind?
Drugs can differ enormously in effect, dosage and risk. Therefore, always read carefully about the drug before taking anything. Therefore always check a website with reliable information such as unity, psychonautwiki.org, tripsit.me. Pay close attention to the dosage. For some substances it is about micrograms! So make sure you have a good reliable scale that can weigh in milligrams.
And if you decide to take a new substance, always start with a low dose, to see how you react to that substance.